 Junli Liu Professor of Endocrinology, Shanghai Jiao Tong University School of Medicine, Principal Investigator, Shanghai Jiao Tong University Affiliated 6th People's Hospital, Shanghai Diabetes Institute. National Science Fund for Excellent Young Scholars , National Overseas High-level Talents， Dr. Liu has been engaged in the study of metabolic diseases such as obesity and diabetes. He has published 2 reseach papers in <Cell Metabolism> and 1 paper in <Science Translation Medicine> as corresponding author, and 3 research papers in <Cell> and 1 paper in <Nature Medicine> as first or co-first author. In response to Dr. Liu's previous work, Prof. Matthias H. Tschop, a member of the German National Academy of Sciences, published a peer review in Nature Medicine commenting that Dr. Liu’s research is an important contribution to overcoming the challenge in metabolism research. Collectively, his published has been highlighted for 6 times by different famous experts in <Nature Medicine>, <Nature Reviews Drug Discovery>, <Nature Reviews Endocrinology>, <Nature Reviews Nephrology> and <Cancer Discovery>. 2000 Sep. — 2004 July Bachelor College of Chemistry, Nankai University 2004 Sep. — 2009 July Ph.D. Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences Mentor: Prof. Junying Yuan (Academician of American Academy of Sciences and American Academy of Arts and Sciences) 2009 July — 2011 Dec. Research assistant Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences Junying Yuan's Team 2012 Jan. — 2012 May Postdoctoral Fellow Massachusetts Institute of Technology （MIT）, Koch Institute Robert S. Langer's Research Team (Academician of American Academy of Science, Engineering and Medicine) in MIT Koch Institute 2012 June — 2016 Jan. Postdoctoral Fellow Boston Children's Hospital, Harvard Medical School Umut Ozcan's Research Team 2016 Jan. — Now Principal Investigator, Professor Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Diabetes Mellitus Shanghai Diabetes Research institute Shanghai Jiaotong University Affiliated Sixth People's Hospital Educational Background & Working Experience Publications [1] Gang Wei#, Honglin Sun#, Kai Dong#,
Libing Hu#, Qi Wang#, Qian Zhuang#, Yan Zhu#,
Xianjing Zhang, Yaodi Shao, Huiru Tang, Zhenfei Li, Suzhen Chen, Junxi Lu,
Yibing Wang, Xinxin Gan, Tao P. Zhong, Dingkun Gui, Xiaoyong Hu, Linhui Wang*,
Junli Liu* “The thermogenic activity of adjacent adipocytes fuels the
progression of clear cell renal cell carcinoma and
compromises anti-tumor therapeutic efficacy”. Cell Metabolism , 2021,
October. 33,1-19 [2] Suzhen Chen#; Xiaoxiao Liu#; Chao Peng; Chang Tan; Honglin Sun; He Liu; Yao Zhang; Ping Wu; Can Cui; Chuchu Liu; Di Yang; Zhiqiang Li; Junxi Lu; Jian Guan; Xisong Ke; Renxiao Wang; Xiaohai Bo; Xiaojun Xu*; Junfeng Han*; Junli Liu*; The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity, Cell Metabolism , 2021, In Press [3] Pan Gao#, Liliang Li#, Liu Yang, Dingkun Gui, Jiarong Zhang, Junfeng Han, Jiajia Wang, Niansong Wang, Junxi Lu, Suzhen Chen, Liping Hou, Honglin Sun, Liping Xie, Jian Zhou, Chao Peng, Yan Lu, Xuemei Peng, Cunchuan Wang, Ji Miao, Umut Ozcan, Yu Huang, Weiping Jia and Junli Liu*. “Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFβ1”. Science Translational Medicine , 2019 Sep 18 ; 11 (510) [4] Honglin Sun#, Gang Wei#*, Junxi Lu, Ji Miao*, Junli Liu*, Suzhen Chen*. “Inhibition of XBP1sUbiquitination enhances its protein stability and improvesglucose homeostasis”，Metab. Clin. Exp., 2019, (105) 154046 [5] Junli Liu, Dorina Ibi, Koji Taniguchi, Jaemin Lee, Hilde Herrema, Bedia Akosman, Patrick Mucka, Mario Andres Salazar Hernandez, Sang Won Park, Michael Karin & Umut Ozcan. “Inflammation Improves Glucose Homeostasis Through IKKβ-XBP1s Interaction”Cell , 2016 Nov 3; 167(4):1052-1066 [6] Jaemin Lee#, Junli Liu#（co-first author）, Xudong Feng, Mario Andrés Salazar Hernández, Patrick Mucka, Dorina Ibi, Jae Won Choi & Umut Ozcan，“Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice”，Nature Medicine , 2016，229 (9): 1023-1032 [7] Junli Liu, Jaemin Lee, Mario Andres Salazar Hernandez, Ralph Mazitschek, and Umut Ozcan. “Treatment of Obesity with Celastrol”. Cell , 2015, 161: 999-1011 [8] Junli Liu#, Hongguang Xia#, Minsu Kim, Lihua Xu, Ying Li, Lihong Zhang, Yu Cai, Helin Vakifahmetoglu Norberg, Tao Zhang, Tsuyoshi Furuya, Minzhi Jin, Zhimin Zhu, Huanchen Wang, Jia Yu, Yanxia Li, Yan Hao, Augustine Choi, Hengming Ke, Dawei Ma, and Junying Yuan.“Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13”. Cell , 2011, 147: 223-234 Funds and talent plans gained by team members Suzhen Chen - National Science Foundation for Young Scientists of China. Suzhen Chen -Shanghai Science and Technology Development Sailing Project. Pan Gao-Shanghai Science and Technology Development Sailing Project. Gang Wei- National Science Foundation for Post-doctoral Scientists of China. Grants information 2016-2019 National Overseas High-level Talents, Principal Investigator.
2017-2020 National Science Fund for Excellent Young Scholars, Grant NO. 31722028, Principal Investigator. 2018-2020 Training Program of the Major Research Plan of the National Natural Science Foundation of China, Grant NO. 91857111, Principal Investigator. 2017-2021 National Natural Science Foundation of China, Grant NO. 81770797, Principal Investigator. 2018-2020 National Science & Technology Major Project, Grant NO. 2018ZX09711002-001-008, Principal Investigator of sub-project.
2019-2023 National key R&D Program of China, Grant NO. 2018YFA0800600, Principal Investigator of sub-project. 2020-2023 “Dawn” Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission, Grant NO. 20SG10, Principal Investigator of sub-project. 2020-2023 International Cooperation Project supported by the Shanghai Committee of Science and Technology, Grant NO. 20410713200, Principal Investigator. The goal of this project is to develop new anti-obesity drug.National Science Fund for Excellent Young Scholars，2018-2020 Major Project for“Significant New Drugs Development”of China during the 13th Five-year Plan period. (head of a sub project，2018-2020) National Natural Science Foundation of China (General Program) Shanghai S&T International Cooperation Program (2016-2019) Shanghai Jiaotong University-Gaofeng Clinical Medicine Grant Support SJTU-CUHK Cooperation Fund |