刘军力实验室
Junli Liu Laboratory

Junli Liu
Professor of Endocrinology, Shanghai Jiao Tong University School of Medicine,
Principal Investigator, Shanghai Jiao Tong University Affiliated 6th People's Hospital, Shanghai Diabetes Institute.
National Science
Fund for Excellent Young Scholars ,
National Overseas High-level Talents,
Dr. Liu has been engaged in the study of metabolic diseases such as obesity and diabetes. He has published 2 reseach papers in <Cell Metabolism> and 1 paper in <Science Translation Medicine> as corresponding author, and 3 research papers in <Cell> and 1 paper in <Nature Medicine> as first or co-first author. In response to Dr. Liu's previous work, Prof. Matthias H. Tschop, a member of the German National Academy of Sciences, published a peer review in Nature Medicine commenting that Dr. Liu’s research is an important contribution to overcoming the challenge in metabolism research. Collectively, his published has been highlighted for 6 times by different famous experts in <Nature Medicine>, <Nature Reviews Drug Discovery>, <Nature Reviews Endocrinology>, <Nature Reviews Nephrology> and <Cancer Discovery>.

2000 Sep. — 2004 July      Bachelor

                                           College of Chemistry, Nankai University

2004 Sep. — 2009 July      Ph.D.

                                           Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

                                           Mentor: Prof. Junying Yuan

                                           (Academician of American Academy of Sciences and American Academy of Arts and Sciences)

2009 July — 2011 Dec.      Research assistant

                                           Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

                                           Junying Yuan's Team

2012 Jan. — 2012 May      Postdoctoral Fellow

                                           Massachusetts Institute of Technology (MIT), Koch Institute

                                           Robert S. Langer's Research Team

                                           (Academician of American Academy of Science, Engineering and Medicine) in MIT Koch Institute

2012 June — 2016 Jan.      Postdoctoral Fellow

                                           Boston Children's Hospital, Harvard Medical School

                                           Umut Ozcan's Research Team

2016 Jan. — Now               Principal Investigator, Professor

                                           Shanghai Jiao Tong University School of Medicine

                                           Shanghai Key Laboratory of Diabetes Mellitus

                                           Shanghai Diabetes Research institute

                                           Shanghai Jiaotong University Affiliated Sixth People's Hospital


Educational Background & Working Experience

Publications

[1] Gang Wei#, Honglin Sun#, Kai Dong#, Libing Hu#, Qi Wang#, Qian Zhuang#, Yan Zhu#, Xianjing Zhang, Yaodi Shao, Huiru Tang, Zhenfei Li, Suzhen Chen, Junxi Lu, Yibing Wang, Xinxin Gan, Tao P. Zhong, Dingkun Gui, Xiaoyong Hu, Linhui Wang*, Junli Liu* “The thermogenic activity of adjacent adipocytes fuels the progression of clear cell renal cell carcinoma and compromises anti-tumor therapeutic efficacy”. Cell Metabolism , 2021, October. 33,1-19
[2] Suzhen Chen#; Xiaoxiao Liu#; Chao Peng; Chang Tan; Honglin Sun; He Liu; Yao Zhang; Ping Wu; Can Cui; Chuchu Liu; Di Yang; Zhiqiang Li; Junxi Lu; Jian Guan; Xisong Ke; Renxiao Wang; Xiaohai Bo; Xiaojun Xu*; Junfeng Han*; Junli Liu*; The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity, Cell  Metabolism , 2021, In Press
[3] Pan Gao#, Liliang Li#, Liu Yang, Dingkun Gui, Jiarong Zhang, Junfeng Han, Jiajia Wang, Niansong Wang, Junxi Lu, Suzhen Chen, Liping Hou, Honglin Sun, Liping Xie, Jian Zhou, Chao Peng, Yan Lu, Xuemei Peng, Cunchuan Wang, Ji Miao, Umut Ozcan, Yu Huang, Weiping Jia and Junli Liu*. “Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFβ1”. Science Translational Medicine , 2019 Sep 18 ; 11 (510)
[4] Honglin Sun#, Gang Wei#*, Junxi Lu, Ji Miao*, Junli Liu*, Suzhen Chen*. “Inhibition of XBP1sUbiquitination enhances its protein stability and improvesglucose homeostasis”,Metab. Clin. Exp., 2019, (105) 154046
[5] Junli Liu, Dorina Ibi, Koji Taniguchi, Jaemin Lee, Hilde Herrema, Bedia Akosman, Patrick Mucka, Mario Andres Salazar Hernandez, Sang Won Park, Michael Karin & Umut Ozcan. “Inflammation Improves Glucose Homeostasis Through IKKβ-XBP1s Interaction”Cell , 2016 Nov 3; 167(4):1052-1066
[6] Jaemin Lee#, Junli Liu#(co-first author), Xudong Feng, Mario Andrés Salazar Hernández, Patrick Mucka, Dorina Ibi, Jae Won Choi & Umut Ozcan,“Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice”,Nature Medicine , 2016,229 (9): 1023-1032
[7] Junli Liu, Jaemin Lee, Mario Andres Salazar Hernandez, Ralph Mazitschek, and Umut Ozcan. “Treatment of Obesity with Celastrol”. Cell , 2015, 161: 999-1011
[8] Junli Liu#, Hongguang Xia#, Minsu Kim, Lihua Xu, Ying Li, Lihong Zhang, Yu Cai, Helin Vakifahmetoglu Norberg, Tao Zhang, Tsuyoshi Furuya, Minzhi Jin, Zhimin Zhu, Huanchen Wang, Jia Yu, Yanxia Li, Yan Hao, Augustine Choi, Hengming Ke, Dawei Ma, and Junying Yuan.“Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13”. Cell , 2011, 147: 223-234

Funds and talent plans gained by team members

Suzhen Chen - National Science Foundation for Young Scientists of China.

Suzhen Chen -Shanghai Science and Technology Development Sailing Project.

Pan Gao-Shanghai Science and Technology Development Sailing Project.

Gang Wei- National Science Foundation for Post-doctoral Scientists of China.

Grants information

2016-2019  National Overseas High-level Talents, Principal Investigator.

2017-2020  National Science Fund for Excellent Young Scholars, Grant NO. 31722028, Principal Investigator.

2018-2020  Training Program of the Major Research Plan of the National Natural Science Foundation of China, Grant NO.                      91857111, Principal Investigator.

2017-2021  National Natural Science Foundation of China, Grant NO. 81770797, Principal Investigator.

2018-2020  National Science & Technology Major Project, Grant NO. 2018ZX09711002-001-008, Principal Investigator of                       sub-project.

2019-2023  National key R&D Program of China, Grant NO. 2018YFA0800600, Principal Investigator of sub-project.

2020-2023  “Dawn” Program of Shanghai Education Development Foundation and Shanghai Municipal Education                                    Commission, Grant NO. 20SG10, Principal Investigator of sub-project.

2020-2023  International Cooperation Project supported by the Shanghai Committee of Science and Technology, Grant                          NO. 20410713200, Principal Investigator.


The goal of this project is to develop new anti-obesity drug.National Science Fund for Excellent Young Scholars,2018-2020

Major Project for“Significant New Drugs Development”of China during the 13th Five-year Plan period. (head of a sub project,2018-2020)

National Natural Science Foundation of China (General Program)

Shanghai S&T International Cooperation Program (2016-2019)

Shanghai Jiaotong University-Gaofeng Clinical Medicine Grant Support

SJTU-CUHK Cooperation Fund