刘军力,复旦大学代谢与整合生物学研究院研究员,博导,国家基金委“优青”(2017),国家中组部“海外高层次人才”获得者(2016)。刘博士获得上海市教委“曙光计划”,北美华人糖尿病学会“青年科学家奖”(Chinese-American Diabetes Association,Junior Investigator Award)、生物物理学会代谢生物学分会“青年科学家奖”和上海市卫生系统“银蛇奖”等。主持基金委重点项目、基金委重大计划集成项目(首席)、重大计划培育项目和科技部重点专项(课题负责人)等多项课题。刘博士还担任Elsevier出版集团Metabolism Open期刊主编,中国生物化学与分子生物学会代谢专业分会副秘书长、中国生理病理学会代谢专业分会副秘书长和中国生物物理学会代谢生物学分会理事等学术职务。 刘博士致力于研究脂肪能量代谢的新型调控机制及其生理病理作用,取得了一系列研究成果。刘博士以第一作者在Cell 发表3篇研究论文,以最后(含唯一)通讯在Cell Metabolism (3篇)、Science Translational Medicine、Nature Communication、Advanced Science 和Cell Reports等期刊发表19篇研究论文,其中单篇引用569次,获评ESI“高被引论文”。国际权威期刊Nature Medicine 和Nature Reviews Drug Discovery Press“2021年度最受欢迎中国论文”奖;他还应邀在Cell Metabolism期刊发表亮点评述(Voice),介绍自己的研究成果。 2000年—2004年 本科 南开大学化学院 2004年—2009年 博士研究生 中国科学院上海有机化学研究所 导师:袁钧瑛教授(三院院士:美国科学院院士、美国艺术与科学院院士、美国科学促进会会士) 2009年—2011年 助理研究员 中国科学院上海有机化学研究所 袁钧瑛课题组 2011年—2012年 博士后 麻省理工学院 (MIT) Koch Institute, Robert S. Langer(三院院士:美国科学院院士、美国医学院院士、美国工程学院院士) 课题组 2012年—2016年 博士后 哈佛大学医学院,附属儿童医院内分泌系 Umut Ozcan 课题组 2016年—2025年 博导,研究员 上海交通大学医学院 上海市糖尿病研究所,上海交通大学附属第六人民医院 2025年—至今 博导,研究员 复旦大学 复旦大学代谢与整合生理学研究院 已经发表文章(* corresponding author) 1, Ning Wang1#, Sijia Lu1#, Ziyi Cao2#, Huimin Li3, Junting Xu1, Qian Zhou1, Hanrui Yin1, Qiqi Qian1, Xianjing Zhang1, Mijia Tao1, Quanxin Jiang1, Peihui Zhou1, Liaoyuan Zheng1, Liu Han1, Hongtao Li1, Limin Yin1, Yunqing Gu1, Xuefeng Dou1, Haipeng Sun4, Wei Wang1, Hai-long Piao5, Fuming Li6, Yingjie Xu2, Weiwei Yang3*, Suzhen Chen1*, Junli Liu1,7*, “Pyruvate Metabolism Enzyme DLAT Promotes Tumorigenesis by Suppressing Leucine Catabolism”, (Cell Metabolism, In press,2025). 2, Gang Wei#, Honglin Sun#, Kai Dong#, Libing Hu#, Qi Wang#, Qian Zhuang#, Yan Zhu#, Xianjing Zhang, Yaodi Shao, Huiru Tang, Zhenfei Li, Suzhen Chen, Junxi Lu, Yibing Wang, Xinxin Gan, Tao P. Zhong, Dingkun Gui, Xiaoyong Hu, Linhui Wang*, Junli Liu* “The thermogenic activity of adjacent adipocytes fuels the progression of clear cell renal cell carcinoma and compromises anti-tumor therapeutic efficacy”. Cell Metabolism, 2021, October 5. 33 (10),2021-2039. 3, Suzhen Chen*#, Xiaoxiao Liu#, Chao Peng, Chang Tan, Honglin Sun, He Liu, Yao Zhang, Ping Wu, Can Cui, Chuchu Liu, Di Yang, Zhiqiang Li, Junxi Lu, Jian Guan, Xisong Ke, Renxiao Wang, Xiaohai Bo, Xiaojun Xu*, Junfeng Han*, Junli Liu*. “The Phytochemical Hyperforin Triggers Thermogenesis in Adipose Tissue via a Dlat-AMPK Signaling Axis to Curb Obesity”. Cell Metabolism, 2021, Mar. 33(3):565-580. 4, Pan Gao#, Liliang Li#, Liu Yang, Dingkun Gui, Jiarong Zhang, Junfeng Han, Jiajia Wang, Niansong Wang, Junxi Lu, Suzhen Chen, Liping Hou, Honglin Sun, Liping Xie, Jian Zhou, Chao Peng, Yan Lu, Xuemei Peng, Cunchuan Wang, Ji Miao, Umut Ozcan, Yu Huang, Weiping Jia* and Junli Liu*. “Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFβ1”. Science Translational Medicine, 2019 Sep 18.11(510), DOI: 10.1126/scitranslmed.aaw2050; PMID: 31534017. 5, Suzhen Chen1#*, Yanping Wang2#, Qian Zhou1#, Quanxin Jiang1, Qiqi Qian1, Chuchu Liu1, Peihui Zhou1, Jie Xiong1, Yao Zhang1, Ning Wang1, Limin Yin1, Junli Liu1*, “Myristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity”. Nature Communications, 2025 Jan;16(1):651. doi: 10.1038/s41467-025-56026-2. 6, Jie Xiong, Ying Xu, Ning Wang, Shengming Wang, Yao Zhang, Sijia Lu, Xiaoman Zhang, Xingxing Liang, Chuchu Liu, Quanxin Jiang, Junting Xu, Qiqi Qian, Peihui Zhou, Limin Yin, Feng Liu, Suzhen Chen*, Shankai Yin*, Junli Liu*, “Obstructive Sleep Apnea Syndrome Exacerbates NASH Progression via Selective Autophagy-Mediated Eepd1 Degradation” Advanced Science. 2024, 11(35):e2405955, DOI:10.1002/advs.202405955. 7, Liping Xie, Yanmei Yuan, Simiao Xu, Sijia Lu, Jinyang Gu, Yanping Wang, Yibing Wang, Xianjing Zhang, Suzhen Chen, Jian Li, Junxi Lu, Honglin Sun, Ruixiang Hu, Hailong Piao, Wen Wang, Cunchuan Wang, Jing Wang, Na Li, Morris F. White, Liu Han, Weiping Jia, Ji Miao, Junli Liu. “Downregulation of hepatic Ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex”, Cell Reports, 2022, Oct. 41: 111498. 8, Honglin Sun#, Gang Wei*#, Junxi Lu, Ji Miao*, Junli Liu*, Suzhen Chen*. “Inhibition of XBP1s ubiquitination enhances its protein stability and improvesglucose homeostasis”, Metabolism. Clin. Exp.,DOI:10.1016/j.metabol.2019.154046; PMID:31837300. 9, Yao Zhang, Quanxin Jiang,Xuemei Fan, Junli Liu*, Suzhen Chen* “Coagulation factor FVII fine-tunes hepatic steatosis by blocking AKT-CD36-mediated fatty acid uptake” , Diabetes, 2024, 73(5):1-20. 10, Yanmei Yuan, Junting Xu, Quanxin Jiang, Chuanxin Yang, Ning Wang, Xiaolong Liu, Hai-long Piao, Sijia Lu, Xianjing Zhang, Liu Han, Zhiyan Liu, Jiabin Cai*, Fang Liu*, Suzhen Chen*, Junli Liu*, “Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis”. Journal of Experimental & Clinical Cancer Research. 2024, 43(1):133. DOI: 10.1186/s13046-024-03047-2.9. 11, Zu-Guo Zheng, Xin Zhang, Xiao-Xiao Liu, Xiu-Xiu Jin, Lunzhi Dai, Hui-Min Cheng, Junli Liu*, Hui-Jun Li*, Ping Li*, Xiaojun Xu*. “Inhibition of HSP90β Improves Lipid Homeostasis Disorder by Promoting Mature SREBPs Ubiquitin-proteasome Degradation”. Theranostics, 2019;9(20); DOI:10.7150/thno.36505. 12, Yao Zhang, Yibing Wang*, Junli Liu*, “Friend or foe for obesity: how hepatokines remodel adipose tissues and translational perspective”, Genes & Diseases, 2021, https://doi.org/10.1016/j.gendis.2021.12.011. 13, Sijia Lu, Yibing Wang, Junli Liu*, “TNF-α signaling in non-alcoholic steatohepatitis and targeted therapies”, Journal of Genetics and Genomics, 2021, (49): 269-278。 https://doi.org/10.1016/j.jgg.2021.09.009. 14, Yanping Wang, Jie Xiong, Yanmei Yuan, Chao Peng, Ping Wu, Yibing Wang, Junxi Lu, Yue Yin, Junting Xu, Suzhen Chen, Junli Liu*, “Suppression of RIP1 activity via S415 dephosphorylation ameliorates obesity-related hepatic insulin resistance”, Obesity, 2022 Mar;30(3):680-693. doi: 10.1002/oby.23361. Epub 2022 Feb 13. 15, Chuchu Liu*,1, Yao Zhang*,1, Ning Wang1, Junting Xu1, Xingxing Liang3, Jie Xiong1, Sijia Lu1, Peihui Zhou1, Yanping Wang#, 1,2, Junli Liu#,1, Suzhen Chen#,1“Betaine–homocysteine methyltransferase promotes adipocyte commitment and insulin resistance via p38 MAPK/Smad signaling”,Obesity, 2022, Accepted. 16, Gang Wei, Honglin Sun, Jun-li Liu, Kai Dong, Junli Liu* and Min Zhang*. “Indirubin, a small molecular deriving from connectivity map (CMAP) screening, ameliorates obesity-induced metabolic dysfunction by enhancing brown adipose thermogenesis and white adipose browning”, 2020,Nutrition & Metabolism, 17:21 DOI:10.1186/s12986-020-00440-4. 17, Sijia Lu, Suzhen Chen*, Ji Miao*, Junli Liu*. “Comments on ‘Downregulation of hepatic Ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex’”, Journal of Molecular Cell Biology, 2023 Aug 3;15(4):mjad026. doi: 10.1093/jmcb/mjad026. 18, Yaodi Shao# , Zhi Yao#, Junyi Zhou, Miao Yu, Suzhen Chen, Yanmei Yuan, Liu Han*, Liqin Jiang* and Junli Liu*. “A novel small compound TOIDC suppresses lipogenesis via SREBP1-dependent signaling to curb MAFLD”, Nutrition & Metabolism, 2022 Dec 6;19(1):80. doi: 10.1186/s12986-022-00713-0. 19, Quanxin Jiang, Ning Wang, Sijia Lu, Jie Xiong, Yanmei Yuan*, Junli Liu*, Suzhen Chen*. “Targeting hepatic ceruloplasmin mitigates nonalcoholic steatohepatitis by modulating bile acid metabolism”, Journal of Molecular Cell Biology. accepted. 20, Junli Liu#, Jaemin Lee#, Mario Andres Salazar Hernandez, Ralph Mazitschek, and Umut Ozcan. “Treatment of Obesity with Celastrol”. Cell, 2015, 161: 999-1011.(co-first auther)PMID: 26000480 21, Junli Liu, Dorina Ibi, Koji Taniguchi, Jaemin Lee, Hilde Herrema, Bedia Akosman, Patrick Mucka, Mario Andres Salazar Hernandez, Sang Won Park, Michael Karin & Umut Ozcan. “Inflammation Improves Glucose Homeostasis Through IKKβ-XBP1s Interaction” 2016, Cell, 2016 Nov 3;167(4):1052-1066.e18; DOI: 10.1016/j.cell.2016.10.015; PMID: 27814504 22, Junli Liu, Hongguang Xia, Minsu Kim, Lihua Xu, Ying Li, Lihong Zhang, Yu Cai, Helin Vakifahmetoglu Norberg, Tao Zhang, Tsuyoshi Furuya, Minzhi Jin, Zhimin Zhu, Huanchen Wang, Jia Yu, Yanxia Li, Yan Hao, Augustine Choi, Hengming Ke, Dawei Ma, and Junying Yuan.“Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13”. Cell, 2011, 147: 223-234. PMID: 21962518 23, Jaemin Lee#, Junli Liu#(co-first author), Xudong Feng, Mario Andrés Salazar Hernández, Patrick Mucka, Dorina Ibi, Jae Won Choi & Umut Ozcan. “Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice”,Nature Medicine,2016 Sep;22(9):1023-32; doi:10.1038/nm.4145; PMID: 27479085 24,Peihui Zhou, Ning Wang, Sijia Lu, Jie Xiong, Yao Zhang, Quanxin Jiang, Qiqi Qian, Qian Zhou, Junli Liu*, Suzhen Chen*, “Dihydrolipoamide S-acetyltransferase activation alleviates diabetic kidney disease via AMPK-autophagy axis and mitochondrial protection”. Translational Research. 2024, 274:81-100. doi: 10.1016/j.trsl.2024.09.005. 25,Sijia Lu, Quanxin Jiang, Peihui Zhou, Limin Yin, Ning Wang, Junting Xu, Qiqi Qian, Mijia Tao, Hanrui Yin, Liu Han, Yunqing Gu, Fei Gao, Junli Liu*, Suzhen Chen*, “Targeting Dlat-Trpv3 pathway by hyperforin elicits non-canonical promotion of adipose thermogenesis as an effective anti-obesity strategy” J Adv Res, 2024,S2090-1232(24)00555-1. doi: 10.1016/j.jare.2024.11.035. 教育和工作经历 |
陈素贞 交大九龙奖
陈素贞 国自然面上
陈素贞 国自然青年
陈素贞 临港实验室
陈素贞 启明星计划
陈素贞 扬帆计划
陈素贞 国自然面上
陈素贞 优青培育
韩柳 博新计划
韩柳 博后面上
韩柳 院内国青培育
袁艳美 博后面上
袁艳美 国青包干制
魏刚 国家博后基金
本课题组成员获得基金和人才计划
● 2016 国家中组部“海外高层次人才”
● 2017 国家基金委“优青”
● 2022 北美华人糖尿病学会青年科学家奖Chinese-American Diabetes Association,Junior Investigator Award (全球每年2人获奖)
● 2021上海市卫生系统“银蛇奖”获得者
● 2021 青年科学家奖,生物物理学会代谢分会(全国每年2人获奖)
● 2020 上海市教育基金委“曙光学者”
● 2016 Harvard Chinese Life Science Yongjin Research Award
● 2016 年哈佛大学华人学者生命科学涌金奖
获得荣誉和人才计划