刘军力实验室

Junli Liu Laboratory

1, Ning Wang1#, Sijia Lu1#, Ziyi Cao2#, Huimin Li3, Junting Xu1, Qian Zhou1, Hanrui Yin1, Qiqi Qian1, Xianjing Zhang1, Mijia Tao1, Quanxin Jiang1, Peihui Zhou1, Liaoyuan Zheng1, Liu Han1, Hongtao Li1, Limin Yin1, Yunqing Gu1, Xuefeng Dou1, Haipeng Sun4, Wei Wang1, Hai-long Piao5, Fuming Li6, Yingjie Xu2, Weiwei Yang3*, Suzhen Chen1*, Junli Liu1,7*, “Pyruvate Metabolism Enzyme DLAT Promotes Tumorigenesis by Suppressing Leucine Catabolism”, (Cell Metabolism, In press，2025).

2, Gang Wei#, Honglin Sun#, Kai Dong#, Libing Hu#, Qi Wang#, Qian Zhuang#, Yan Zhu#, Xianjing Zhang, Yaodi Shao, Huiru Tang, Zhenfei Li, Suzhen Chen, Junxi Lu, Yibing Wang, Xinxin Gan, Tao P. Zhong, Dingkun Gui, Xiaoyong Hu, Linhui Wang*, Junli Liu* “The thermogenic activity of adjacent adipocytes fuels the progression of clear cell renal cell carcinoma and compromises anti-tumor therapeutic efficacy”. Cell Metabolism, 2021, October 5. 33 (10),2021-2039.

3, Suzhen Chen*#, Xiaoxiao Liu#, Chao Peng, Chang Tan, Honglin Sun, He Liu, Yao Zhang, Ping Wu, Can Cui, Chuchu Liu, Di Yang, Zhiqiang Li, Junxi Lu, Jian Guan, Xisong Ke, Renxiao Wang, Xiaohai Bo, Xiaojun Xu*, Junfeng Han*, Junli Liu*. “The Phytochemical Hyperforin Triggers Thermogenesis in Adipose Tissue via a Dlat-AMPK Signaling Axis to Curb Obesity”. Cell Metabolism, 2021, Mar. 33(3):565-580.

4, Pan Gao#, Liliang Li#, Liu Yang, Dingkun Gui, Jiarong Zhang, Junfeng Han, Jiajia Wang, Niansong Wang, Junxi Lu, Suzhen Chen, Liping Hou, Honglin Sun, Liping Xie, Jian Zhou, Chao Peng, Yan Lu, Xuemei Peng, Cunchuan Wang, Ji Miao, Umut Ozcan, Yu Huang, Weiping Jia* and Junli Liu*. “Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFβ1”. Science Translational Medicine, 2019 Sep 18.11(510), DOI: 10.1126/scitranslmed.aaw2050; PMID: 31534017.

5, Suzhen Chen1#*, Yanping Wang2#, Qian Zhou1#, Quanxin Jiang1, Qiqi Qian1, Chuchu Liu1, Peihui Zhou1, Jie Xiong1, Yao Zhang1, Ning Wang1, Limin Yin1, Junli Liu1*, “Myristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity”. Nature Communications, 2025 Jan;16(1):651. doi: 10.1038/s41467-025-56026-2.

6, Jie Xiong, Ying Xu, Ning Wang, Shengming Wang, Yao Zhang, Sijia Lu, Xiaoman Zhang, Xingxing Liang, Chuchu Liu, Quanxin Jiang, Junting Xu, Qiqi Qian, Peihui Zhou, Limin Yin, Feng Liu, Suzhen Chen*, Shankai Yin*, Junli Liu*, “Obstructive Sleep Apnea Syndrome Exacerbates NASH Progression via Selective Autophagy-Mediated Eepd1 Degradation” Advanced Science. 2024, 11(35):e2405955, DOI：10.1002/advs.202405955.

7, Liping Xie, Yanmei Yuan, Simiao Xu, Sijia Lu, Jinyang Gu, Yanping Wang, Yibing Wang, Xianjing Zhang, Suzhen Chen, Jian Li, Junxi Lu, Honglin Sun, Ruixiang Hu, Hailong Piao, Wen Wang, Cunchuan Wang, Jing Wang, Na Li, Morris F. White, Liu Han, Weiping Jia, Ji Miao, Junli Liu. “Downregulation of hepatic Ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex”, Cell Reports, 2022, Oct. 41: 111498.

8, Honglin Sun#, Gang Wei*#, Junxi Lu, Ji Miao*, Junli Liu*, Suzhen Chen*. “Inhibition of XBP1s ubiquitination enhances its protein stability and improvesglucose homeostasis”, Metabolism. Clin. Exp.，DOI:10.1016/j.metabol.2019.154046; PMID：31837300.

9, Yao Zhang， Quanxin Jiang，Xuemei Fan, Junli Liu*, Suzhen Chen* “Coagulation factor FVII fine-tunes hepatic steatosis by blocking AKT-CD36-mediated fatty acid uptake” , Diabetes, 2024, 73(5)：1-20.

10, Yanmei Yuan, Junting Xu, Quanxin Jiang, Chuanxin Yang, Ning Wang, Xiaolong Liu, Hai-long Piao, Sijia Lu, Xianjing Zhang, Liu Han, Zhiyan Liu, Jiabin Cai*, Fang Liu*, Suzhen Chen*, Junli Liu*, “Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis”. Journal of Experimental & Clinical Cancer Research. 2024, 43(1):133. DOI: 10.1186/s13046-024-03047-2.9. 11, Zu-Guo Zheng, Xin Zhang, Xiao-Xiao Liu, Xiu-Xiu Jin, Lunzhi Dai, Hui-Min Cheng,  Junli Liu*, Hui-Jun Li*, Ping Li*, Xiaojun Xu*. “Inhibition of HSP90β Improves Lipid Homeostasis Disorder by Promoting Mature SREBPs Ubiquitin-proteasome Degradation”. Theranostics， 2019;9(20); DOI:10.7150/thno.36505.  

12, Yao Zhang, Yibing Wang*, Junli Liu*, “Friend or foe for obesity: how hepatokines remodel adipose tissues and translational perspective”, Genes & Diseases, 2021, https://doi.org/10.1016/j.gendis.2021.12.011.

13, Sijia Lu, Yibing Wang, Junli Liu*, “TNF-α signaling in non-alcoholic steatohepatitis and targeted therapies”, Journal of Genetics and Genomics, 2021, (49): 269-278。 https://doi.org/10.1016/j.jgg.2021.09.009.

14, Yanping Wang, Jie Xiong, Yanmei Yuan, Chao Peng, Ping Wu, Yibing Wang, Junxi Lu, Yue Yin, Junting Xu, Suzhen Chen, Junli Liu*, “Suppression of RIP1 activity via S415 dephosphorylation ameliorates obesity-related hepatic insulin resistance”, Obesity, 2022 Mar;30(3):680-693.  doi: 10.1002/oby.23361. Epub 2022 Feb 13.

15, Chuchu Liu*,1, Yao Zhang*,1, Ning Wang1, Junting Xu1, Xingxing Liang3, Jie Xiong1, Sijia Lu1, Peihui Zhou1, Yanping Wang#, 1,2, Junli Liu#,1, Suzhen Chen#,1“Betaine–homocysteine methyltransferase promotes adipocyte commitment and insulin resistance via p38 MAPK/Smad signaling”，Obesity, 2022， Accepted.

16, Gang Wei, Honglin Sun, Jun-li Liu, Kai Dong, Junli Liu* and Min Zhang*. “Indirubin, a small molecular deriving from connectivity map (CMAP) screening, ameliorates obesity-induced metabolic dysfunction by enhancing brown adipose thermogenesis and white adipose browning”, 2020，Nutrition & Metabolism, 17:21 DOI：10.1186/s12986-020-00440-4.

17, Sijia Lu, Suzhen Chen*, Ji Miao*, Junli Liu*. “Comments on ‘Downregulation of hepatic Ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex’”, Journal of Molecular Cell Biology, 2023 Aug 3;15(4):mjad026.  doi: 10.1093/jmcb/mjad026.

18, Yaodi Shao# , Zhi Yao#, Junyi Zhou, Miao Yu, Suzhen Chen, Yanmei Yuan, Liu Han*, Liqin Jiang* and Junli Liu*. “A novel small compound TOIDC suppresses lipogenesis via SREBP1-dependent signaling to curb MAFLD”, Nutrition & Metabolism, 2022 Dec 6;19(1):80.  doi: 10.1186/s12986-022-00713-0.

19, Quanxin Jiang, Ning Wang, Sijia Lu, Jie Xiong, Yanmei Yuan*, Junli Liu*, Suzhen Chen*. “Targeting hepatic ceruloplasmin mitigates nonalcoholic steatohepatitis by modulating bile acid metabolism”, Journal of Molecular Cell Biology. accepted.

20, Junli Liu#, Jaemin Lee#, Mario Andres Salazar Hernandez, Ralph Mazitschek, and Umut Ozcan. “Treatment of Obesity with Celastrol”. Cell, 2015, 161: 999-1011.（co-first auther）PMID: 26000480

21, Junli Liu, Dorina Ibi, Koji Taniguchi, Jaemin Lee, Hilde Herrema, Bedia Akosman, Patrick Mucka, Mario Andres Salazar Hernandez, Sang Won Park, Michael Karin & Umut Ozcan. “Inflammation Improves Glucose Homeostasis Through IKKβ-XBP1s Interaction” 2016, Cell, 2016 Nov 3;167(4):1052-1066.e18; DOI: 10.1016/j.cell.2016.10.015; PMID: 27814504

22, Junli Liu, Hongguang Xia, Minsu Kim, Lihua Xu, Ying Li, Lihong Zhang, Yu Cai, Helin Vakifahmetoglu Norberg, Tao Zhang, Tsuyoshi Furuya, Minzhi Jin, Zhimin Zhu, Huanchen Wang, Jia Yu, Yanxia Li, Yan Hao, Augustine Choi, Hengming Ke, Dawei Ma, and Junying Yuan.“Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13”. Cell, 2011, 147: 223-234. PMID: 21962518

23, Jaemin Lee#, Junli Liu#（co-first author）, Xudong Feng, Mario Andrés Salazar Hernández, Patrick Mucka, Dorina Ibi, Jae Won Choi & Umut Ozcan. “Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice”，Nature Medicine，2016 Sep;22(9):1023-32; doi:10.1038/nm.4145; PMID: 27479085 24，Peihui Zhou, Ning Wang, Sijia Lu, Jie Xiong, Yao Zhang, Quanxin Jiang, Qiqi Qian, Qian Zhou, Junli Liu*, Suzhen Chen*， “Dihydrolipoamide S-acetyltransferase activation alleviates diabetic kidney disease via AMPK-autophagy axis and mitochondrial protection”. Translational Research. 2024, 274:81-100. doi: 10.1016/j.trsl.2024.09.005.

25，Sijia Lu, Quanxin Jiang, Peihui Zhou, Limin Yin, Ning Wang, Junting Xu, Qiqi Qian, Mijia Tao, Hanrui Yin, Liu Han, Yunqing Gu, Fei Gao, Junli Liu*, Suzhen Chen*, “Targeting Dlat-Trpv3 pathway by hyperforin elicits non-canonical promotion of adipose thermogenesis as an effective anti-obesity strategy” J Adv Res， 2024，S2090-1232(24)00555-1. doi: 10.1016/j.jare.2024.11.035.